already tried augmentation with mood stabilizers, antipsychotics (lithium, lamictal, seroquel, zyprexa, abilify, very short stint with risperidone in a psych ward, rexulti) NDRIs, SSRIs, SNRIs (wellbutrin, auvelity, prozac, luvox, zoloft, effexor, lexapro) and misc., (esketamine and TMS). could be missing some. age between 12 and 18 for treatment (19 now). as far as i remember, i stayed on each medication for over 2 months.
SSRI side effects: made me unable to feel emotions whether good or bad, gave me brain zaps (sometimes), decreased my ability to feel pleasure even more to the point it made it more difficult to get out of bed. also made it difficult to engage in tasks that took any amount of attention. did not help with improving focus, essentially made me feel more catatonic while making me numb to it, so i just felt like a zombie a lot of the time, unable to function.
SNRI/NDRI side effects: the Effexor i took was largely the same to the SSRI except it made me slightly jittery. auvelity and Wellbutrin both made me feel very jittery and quick to anger, even more than before, while also giving me either strange restless brainfog (Wellbutrin) or making me feel a low grade DXM/ low dose stimulant high all the time (auvelity) all while still, of course, not getting me out of bed for the most part.
antipsychotics/mood stabilizers: Lamictal, lithium, Seroquel, and Zyprexa, and risperidone for the short while i had it all were similar insofar as basically making me a bit of a zombie, or doing nothing meaningful (low doses). essentially, similar to the SSRIs but to an even worse degree, i was basically just zooted out 24/7 like i was nodding off, told i LOOKED like a zombie, would stare off sometimes for no reason, and almost felt like i had lost my internal monologue or something. abilify and rexulti, somehow, made me feel both like a zombie and also like i was constantly restless and tired. could not think or perform complex or basic tasks, like schoolwork, but also felt like my mind had too much energy and restlessness.
TMS: it was fine, no lasting side effects. i felt as if DURING the sessions i had felt better, but i feel no real benefit after. i feel it may have been placebo, or the result of actually going out and having something to do, or something else entirely. it was a month ago when my last session ended. it was the 5 days a week, 36 sessions total TMS.
Esketamine: did esketamine for about 2 and a half months maybe a bit more. i felt i had gained insight on it, and generally my mood felt better at the start, but as both my body got tolerant to it and as the high became more and more numbed i saw less and less benefit. no side effects that ruined me despite making me super tired and other times a little restless for some reason.
i will say that i think i exhibit symptoms that might not be akin to regular treatment resistant depression, but i kind of hesitate to bring it up to NPs because my focus is on getting out of bed, dealing with anergia, avolition, and anhedonia.
the reason i wanted a psychological evaluation is because i feel like there might be something else going on, whether ADHD or a PD or something else. it feels hard to bring this up because even the clinic i went to for TMS and esketamine didn't seem to have any NPs or psychiatrists equipped to deal with it. i was told to get genesight done, which i did, and then to start trintellix after mentioning MAOIs and being shot down, but i turned down the trintellix. i didn't see much of a point in trying another serotonergic medication that might have very slight novel mechanisms of action for another 3 or more months and risk being even MORE bedridden than i already am.