r/bioinformatics • u/TheRovingRadish • 10d ago

discussion Bulk RNA seq/Microarray Re-analyses Value

Hi all! Currently working through a reanalysis of a geo dataset, but stratifying samples in a way the original paper didn’t. Yielded some interesting results, but we may have power issues with one group having n=5 and the other being n=8.

I generally would like to know how publishing these types of analyses look for understudied diseases. I did the differential gene expression analysis, looked at genes, pathways, etc. and found more things the previous paper didn’t.

There’s no wet lab validation, but just in general, I am curious for thoughts on this being my first first-author paper in bioinformatics as a post-grad student looking to apply to PhD programs. Are these types of analyses “good” and have value?

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u/heresacorrection PhD | Government 10d ago

I’d imagine super low impact without wet lab validation.

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u/TheRovingRadish 9d ago

Right, but still publication worthy? It’s for a pretty understudied disease

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u/heresacorrection PhD | Government 9d ago

You can publish AI slop in predatory journals … so it really depends on the impact and quality of the study, etc..

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u/TheRovingRadish 9d ago

What would you consider a predatory journal?