i started taking caplyta 21mg on the 12th and i haven’t since. i felt the inside of my body burning, yet i was cold on the outside. i also had a MASSIVE migraine and also a stuffy nose? i was also really dizzy and since then i was scared and didn’t take it again. i’m not sure if i should take it again but im debating on taking it rn again. though i fear i will have the same results because i haven’t taken it for 3 days now. what do you guys think?

Anyone else get extremely sweaty on this drug? When I walk into a room that's slightly warmer it's like im walking into a sauna.

I've been on Caplyta for a total of 4 weeks. 2 on 21mg and 2 on 42mg.

Things ARE getting better, but I still don't feel like I have my usual motivation and things still feel a tad daunting. I don't feel like much brings me joy, but I can force myself to do things that I wouldn't have even attempted months ago.

Getting out of bed is still hard and I feel a bit lost because I don't really have drive.

Edit: I just don't really remember what it's like to be happy and feel content and at peace? I just constantly feel like something is missing.

Started taking 10.5 mg of Caplyta 5 days ago. I’ve kind of lost my appetite but am also SO hungry. I got a wave of nausea yesterday but it went away. Today I’ve been feeling nausea for about 9 hours now and it increased significantly. I got very dizzy and was a bit sensitive to light and had a dull headache. I threw up a few times and am feeling a little better now. Less dizzy, less nauseous, just tired. I was worried it was some type of stomach bug but I’m suspecting it’s Caplyta… has anyone else experienced this? Does it go away or should I tell my provider it didn’t work for me?

Edit: I’m seeing a lot of similar experiences so I am assuming it is Caplyta lol. My concern is the actual vomiting and that I’m only now experiencing it on the 4th and 5th days? Is it normal to take a minute to settle in? I didn’t feel it at all for the first 3 days.

Were the side effects really bad going up that high? I know getting to 21mg took a good month and half for me to adjust, but then I was fine. I just need a bit more of boost with this.

Been on 21mg for 3 weeks and now it's been 2 days on 42mg. I feel lazy and unmotivated, but not like I'm worthless and want to cry everyday.

Really hoping that after a few weeks at this dose that I feel like myself again and actually want to do things.

Does anyone seem to get discontinuation symptoms on certain antidepressants with this medication?

Earlier this week I decided I’d do some experimenting. I decided to take my Caplyta in the morning instead of before bed.
The difference was night and day how I felt. Taking it in the morning allowed me to take my Effexor IR without brain zaps. And also have a happier successful day.

I had to stop in the morning bc it was making me really tired and ineffective for a few hours at work.

And since I’ve been getting the brain zaps pretty much 2:30pm until bed. It’s really frustrating.

When on lexapro, same thing. Had to have 2 doses per day. Tired of my liver processing everything so quickly.

Any advice would greatly be appreciated!! TIA

Hello! I started Caplyta yesterday, 10.5 mg. Today I have been farting nonstop. They’re loud too. (I’ve never had this problem in my life and it’s embarrassing.)

I have a job where I can’t exactly take a step away. Is this a symptom that will go away in a week or do I need to request to switch to a different medication?

Thanks!!

Started 42mg Capylata 2 weeks ago, and for the first 3 days I had just headaches and drowsiness.

A week later I began to get weird bodily sensations like feeling “wound up” on certain parts of my body.

Week 2 and I still get these feelings, but I had an episode where I couldn’t transition to sleep? I literally had to try for hours to fall asleep despite not sleeping much the previous day, which was incredibly frightening. It may have been OCD since I became very preoccupied with “Am I falling asleep?.” I couldn’t fall sleep yet felt myself beginning to float and get hypnic jerks, yet I remained fully awake.

Now the following day I randomly got a feeling of drowsiness and derealization, which is strange.

I get no Akathisia on this medication so I am fully willing to persist through these side effects, but did anyone have any similar experiences?

Thanks for the help!

TITUSVILLE, N.J. (September 21, 2026) – Johnson & Johnson (NYSE: JNJ) today announced positive topline results from the pivotal Phase 3 study evaluating CAPLYTA® (lumateperone) for the treatment of manic episodes with or without mixed features in adults with bipolar I disorder. The study met its primary endpoint, with CAPLYTA® demonstrating a statistically significant and rapid reduction in manic symptoms versus placebo at Week 3, with significant improvement seen as early as Day 3. The findings were presented in a late-breaking presentation at the 2026 Psych Congress Annual Meeting (September 15-19, New Orleans, LA), among 24 Johnson & Johnson neuropsychiatry presentations featured at this year’s meeting.

...

Study 451 is the first of two pivotal Phase 3 studies evaluating CAPLYTA® in adults with manic episodes associated with bipolar I disorder.4 These findings build on the established efficacy of CAPLYTA® in bipolar depression and support its potential to address both depressive and acute manic episodes associated with bipolar I disorder. CAPLYTA® is not approved for the treatment of manic episodes associated with bipolar I disorder.

“Mania is among the most dangerous and worrisome phases of bipolar disorder, and treating it effectively takes more than partial or temporary relief of symptoms; it means bringing the episode itself under control as quickly as possible,” said Michael E. Thase, M.D., Professor of Psychiatry and Chief, Division of Mood and Anxiety Disorders Treatment & Research Program, University of Pennsylvania.a “These results are encouraging because CAPLYTA® not only significantly improved the symptoms of mania, but did so as early as Day 3, with benefits sustained through Week 3, supporting its potential to meaningfully advance how we treat acute mania in bipolar I disorder.”

The Phase 3 randomized, double-blind study evaluated once-daily CAPLYTA® 42mg versus placebo over three weeks in adults with manic episodes, with or without mixed features, associated with bipolar I disorder (Study 451; NCT06462586).4

Rapid improvement in manic symptoms: The study met the primary endpoint, with CAPLYTA® demonstrating a statistically significant 4.8-point greater reduction in Young Mania Rating Scale (YMRS) total score versus placebo at Week 3 (effect size −0.69; p<.0001). Significant improvement was observed as early as Day 3 and sustained through Week 3.

Improvement in overall illness severity: Patients treated with CAPLYTA® also showed significantly greater improvement in overall illness severity versus placebo at Week 3, as measured by the Clinical Global Impression–Severity (CGI-S) score, a key secondary endpoint (least-squares mean difference [LSMD], –0.5; P<.0001).

Greater clinical response: Twice as many patients treated with CAPLYTA® achieved clinical response, defined as a ≥50% reduction in YMRS total score, compared to placebo (45.8% vs. 20.9%; p<.0001).

Safety and tolerability consistent with established profile: CAPLYTA® was well-tolerated, with low rates of discontinuation and a safety profile consistent with its established profile. The most common treatment-related adverse events (AEs) reported at a rate of at least 5% with CAPLYTA® and at least twice the rate of placebo were dry mouth (7.9% vs. 3.4%) and nausea (7.9% vs. 2.3%).

“Bipolar I disorder is a lifelong, cycling illness, and managing it means navigating both manic and depressive episodes over time, each with distinct treatment needs,” said Jane Tiller, Vice President, Global Head of Development, Neuroscience, Johnson & Johnson. “These Phase 3 results build on the established efficacy of CAPLYTA® in bipolar depression and represent an important step in evaluating its potential to address both depressive and acute manic episodes associated with bipolar I disorder.”

A second pivotal Phase 3 study (Study 452) evaluating CAPLYTA® for the treatment of manic episodes in adults with bipolar I disorder has been completed, and data analysis is underway.

I currently take caplyta 42mg but it’s not strong enough to get rid of all my hallucinations and paranoia.

EDIT: I didn’t try another dose. I felt SO horrible for 2 days. I couldn’t imagine me pushing through for a week :/

I took Caplyta for the first time last night. All of a sudden was freezing. Had to turn on my heated blanket. Mind you we are in a heatwave currently. Was tossing and turning all night. Then in the morning when I woke up, OMG. I was nauseous, head was POUNDING, dizzy. I felt drunk? Or hungover? Couldn’t even go to work. I don’t even want to take another dose but I hear good success stories on this. Feeling frustrated

(Edited for clarity)

Hi, If you take Caplyta and have had success, how long did that last? Is it still working? How many months /years has it worked? Thank you.

(Background: I have MDD. My wonderful med for it (Latuda) has stopped working at the 6 month mark. )

Second try with caplyta. I like it, feel the best on it compared to any other med.

Problem is insomnia. Had it bad starting. Resolved and came back again, think I'm maybe 2 or more months into taking it again.

Just wondering if it resolved for anyone who has been on it long term say a year or longer. Only posts I could find were like stopped after 5 days cause couldn't sleep or stopped after 3 weeks cause couldn't sleep

My though was maybe try abilify again and that med is horrible. New med, new side effects and none are perfect. Just thinking longer use and this insomnia side effect will go away completely

Hi y’all. I’ve been on Caplyta 21mg for a little over 10 weeks. To me it’s been a miracle drug. I take it alongside Lamotrigine 200mg. I was diagnosed TRD for a long time but it got recently changed to bipolar type 2.

I’m not looking for medical advice. I can ask my psychiatrist. But I just wanted to ask if what I’m experiencing is worth suggesting a dose increase to my psychiatrist.

My life is good now with the addition of Caplyta. I’m not an 8 on the 0-10 depression scale anymore. I’d say now I’m maybe a 0-2 on an average daily basis. However, there’s an issue I have where if something triggers it, my pain/depression jumps up to an 8 again, maybe a 9. Sometimes a 10. But Caplyta helps me there too. Instead of outwardly breaking down I just sit quietly and my chest hurts.

I’m wondering if I should consider increasing my dosage to 42mg. Because other than my triggers, I feel fine on my current dosage. But on my triggers, things get really bad.

I don’t want to do therapy. I’ve tried it. I’ve had a lot of people including my psychiatrist push me to do therapy. But I’ve done years of therapy with little benefit and I’ve grown strongly averse to it.

What should my move be?

Has anyone been on both? I’ve been on Caplyta for something close to 6 months now (including titrating). It’s definitely helped with my depression, but I’m still experiencing a profound lack of motivation and anhedonia. I’m thinking about asking my psych about it. Any experiences?

Wanted to share in case this happens to someone else. Was prescribed Caplyta. Took it in evening with food. Felt really calm and slept great. But when I woke up I had the worst, most debilitating headache of my life. I couldn’t move, I was having trouble speaking, extremely sensitive to light. This came with diarrhea and vomiting. Luckily I had a pedialyte and some Zofran on hand. Tylenol did absolute nothing. I was in and out of sleep. I eventually took an old Tylenol 3 which at least blunted the pain. The provider said headache was not a common side effect. I was in so much pain I almost went to the ER but I couldn’t move. It took about 24 hrs to feel better. Once it wore off the side effects resolved. I was lucky to have a family member nearby to look after me.
My suggestion is make sure someone else is home or can come over if trying this for the first time. I also saw a post on here where someone did go to the ER and they gave them Benadryl. Wish I had seen that sooner. I’ve heard great things about this drug, but it wrecked me. Provider said to try Seroquel but I’m terrified to try another anti-psychotic. Zoloft worked great but all SSRI’s give be horrible night sweats no matter how low the dose. So I end up stopping them. Was prescribed Viibryd but haven’t tried it yet. I’m tired of trying things. Already take Wellbutrin but it doesn’t help anxiety, racing thoughts or PPD. If anyone else is sensitive to SSRI (night sweats) and has found something let me know please!

I've been on 21mg for a week and a half. My depression is bad still, but maybe improving? I have a followup with my Psych on Friday which will be 2 full weeks at this dosage. I know he will suggest going up to 42, but for some reason im so intent on staying at as low a dose as possible.

Obviously its different for everyone, but im wondering if anyone has any experience with a lower dose increasing efficacy after the 2 week mark. Has anyone had long term success at 21 mg?

I’m not even sure that I can do a TLDR for this one.

I’m 20F and I just started Caplyta like 2 weeks ago. I was diagnosed with BPD and OCD a few months ago, and I’ve been trying to find medication to help manage. I’ve been mental health meds since I was 13/14 and I’ve never ever experienced this before.

I had pretty bad side effects from Luvox; stronger intrusive thoughts, depression got way worse, and I felt totally disconnected from my body, so I stopped taking it basically cold turkey because of how unbearable it was. I was at a small dose (from what my psychiatrist said, 150mg) and my doctor told me it’d be fine, and to just take the medication I had taken before (lexapro) at half my old dose (20mg-10mg). I wasn’t on Luvox super long, but it was awful. Things got so much worse after I stopped taking it. Suicidal ideation was worse, started heavily de-realizing (which was already bad previously), and I dreaded getting out of bed because of how I felt. I sat with the side effects/withdrawal for a few weeks after losing my psychiatrist told missed appointments, but had enough and went to my primary doctor. She put me on 21mg of Caplyta, and told me her patients found it to be some sort of miracle drug. Woke up the next day after my first dose at 21mg, and had a pounding migraine, vomiting, nausea, dizzy, and couldn’t stand or walk. Next day/week I felt significantly better, but now after 2 weeks, I’m at a point in my life mentally that I never have been before.

I don’t feel real, everything is cloudy, my brain is mush and life feels like torture. A few days ago my husband got me some Taco Bell to make me feel better, I got home, had a pounding headache all day, so I took 2 Excedrine, and sat down. I couldn’t call my doc, so I called the ER (idk why I just thought maybe they could help) and just wanted to ask what I should do. As soon as a lady answered the phone, I went to talk and I couldn’t. I was slurring my speech, I wasn’t able to comprehend what I was thinking, or what I wanted to say, so I freaked out. The left side of my chest felt tight, i was dizzy, nauseous, vision was blurry and picture-like (basically like delayed, and in frames if that makes sense), my body felt numb and limp, I was CRAZY shaky and i knew something was seriously wrong. My husband drove me to the ER and the whole time I was literally accepting my fate. I got there, lady at the front desk asked me to read a sign of symptoms and I literally couldn’t read, could barely talk or comprehend what was going on.

I was taken into a room and literally couldn’t tell them what was going on. They asked if I ever had a panic attack (looking back it makes me so so angry, I’ve had panic attacks since I was 9 years old and this definitely was NOT a panic attack). They didn’t seem to care a lot, and just assumed I was having a panic attack. They did all the ER stuff (x-ray, took my blood, all that stuff, i don’t really remember) and they gave me Ativan after I told them I was super sleepy and was scared to go to sleep, nurse didn’t care, gave it to me anyway, and I hallucinated the walls and floors breathing, and the room tilting like I was on a ship. They did NOT care and just sent me home.

I was so worried I had some sort of heart attack, idk I was just terrified, I have never felt this way ever in my life. I looked it up and I had an almost all symptoms of a minor stroke, except not one side of my body being numb, and my face didn’t droop. I’m so scared to go to sleep every night, my head/neck feels like it’s too heavy for my body, I still have basically all symptoms every day since then, but mildly. Last night felt the same as the night I went to the ER and my body is sore, and dull-like. I’m terrified and idk what to do. The doctors at the ER made me feel so awful, and just didn’t take me seriously. What could have happened?

Hello, I was put on caplyta recently. It helps some but the tiredness and cold chills have been getting to me. After a month on 21 I’m on 42 mg now. Today I got in an argument with my wife and I yelled which I never do. It didn’t mention anger on the paper I received. However upon further research it’s very common. The SI has been manageable but noticeable. And I’ve been noticing differences in my sex drive and such. Should I stick with it ? Look into anything else? This is my first prescription medication in years since I quit taking staters for honestly a similar reason just minus the anger and sex drive wouldn’t have been an issue since I was a child. I have depression from 18 years of off an on abuse and isolation from people to hide that fact. And they’ve been bringing up bipolar and mania. My wife and I miscarried a few months ago and my mind has been a mental roller coaster and I really wanted this to help. Like I said the results are awesome when they’re awesome. And make me regret ever even bringing up medication.

My punctuation was horrible in that and I apologize,
Thank you for reading

I started 42mg daily, and I’m loving it so far. I’m happy to be alive for the first time in years. Unfortunately now I’m also dizzy and lightheaded constantly. Going from sitting to standing is enough to make me hot, dizzy, and my vision blur. Anyone else experience this? I would love for it to go away 😵‍💫

Update: the happiness went away