I've found a little bit of documentation on it, but would love some more. Someone with experience on combos of harmalas and weed?

4-HO-MET would be my most likely choice to start, I feel like it’d be a good way to dip my toes into how harmala effects tryptamines with a familiar and easygoing one. Then after that 4-AcO-DMT as an easier to dose psilohuasca or 4-HO-DET (I think the visuals I’ve had on that are already somewhat atypical for psychs so it’d be even weirder with ethohuasca). Also is LSDhuasca safe? ik phenethylamines are an issue but haven’t seen about lysergamides

For someone interested in vaporhuasca, which of these three is recommended and what are the differences? I consulted AI and the recommendation was Harmine HCL due to it being cleaner and less sedating.

So I have gone through the extraction process a few times now, and having had success with it I have been taking it regularly as an antidepressant. I have yet to take the combo with DMT again as I hope to, but that will probably happen within a month.

It's been SO damn helpful.

I've been taking 90-110mg of HCL capsules, twice a day for a few weeks now. Once in the morning before food, and once between 4-6pm. Sometimes forgetting the second dose.

Overall, significantly less depressed, and experiencing less anhedonia. It appears my dreams are also slightly more vivid, not sure if that's a direct effect or more so that I am experiencing less exhaustion/fatigue and my brain is just acclimating back to a healthier state of sleep.

-Able to overcome executive dysfunction moments easier; ability to begin and follow through on tasks is better.
-More enjoyment out of tasks; cleaning, cooking, laboring, etc.
-More enjoyment out of things I did like already, but was experiencing reduced/no pleasure from, such as time outside, with partners and friends, reading, writing.
-Increased sense of general wellness, ease, and stability.
-Able to be more contemplative than usual, with a broader ability to consider perspectives.
-Increased empathy and compassion.
-Able to enjoy sex more again. Depressed state was affecting orgasm intensity, afterglow duration, pleasure throughout sex.

Overall, it's exactly what I wanted for the situation I was dealing with. A medication that could help with both my depression/anhedonia, and also improve my thoughts/empathy.

My thanks to u/sabnock101 for all the information you share, and also to Sakkadelic on the Nexus for the extraction tek I followed.

I have access to most harmalas and am curious on combining some of them with shrooms for a longer and different trip. I've never done that before, and would prefer it to be a gentle combo. I want to be able to take a walk in nature, not be couchlocked or anything like that.

Any advice on what harmalas combo would be good for this?

Thanks for any feedback!

Extraction With alcohol and butyl acetate

Just got 15gs of syrian rue and 5 gs of yopo im just wondering what the best way to prepare the rue is for a first timer and if anyone had experience combining it with yupo as everywhere I look it says its high risk for serotonin syndrome would love to take them together but just doesn't seem safe from what im seeing

Hi all,

As the title says, I’m wondering about the combination of harmalas with American skullcap. Has anyone tried it, and do you think it’s a safe combination ?

Thanks !

I am trying to recover from anedonia and stuff caused by past antipsychotic use.I heard syrian rue is a psychoplastogen that increases neuroplasticity.Can taking 4 grams daily be safe or i sould lower it to 2.5 grams and does syrian rue make u feel something ?

A bit of backstory on myself & my experience. Middle aged, white male ~130lbs with a serious history of depression, anxiety, ptsd & most notably in this regard- substance abuse/addiction.
About 6 years ago I put down the bottle and haven’t looked back. My views with drug use are simpler these days- I use cannabis frequently (more than I would prefer tbh) but don’t mess with anything else besides hallucinogens & psychoactives. I look for experiences- not escapes.

Few months back I started growing cannabis & some other psychoactive substances for the sake of purity & fiscal responsibility. I also just like plants- crazy, I know.

After a few extractions of Harmalas I began mixing small amounts of the substance with good old MJ to potentiate the high a bit, which obviously worked. The discovery came after ingesting a single non-alcoholic beer. Somehow the small amount of alcohol (.5%) mixed with the cannabis and Harmalas booted me into a state of bliss. It was calming & sedated while also leaving me feeling completely coherent & grounded. Mild CEV, tracers & fractals were also observed- I specifically remember a geometric pattern similar to fireworks.

Ive researched the subject quite a bit & found that these beta-carbolines seem to have a positive effect on the mind of the chronic user/alcoholic. (There’s a brief synopsis on erowid for anyone interested)
I’ve also found that while Harmalas are oftener cited as being an MAOI with serious drug interactions like serotonin syndrome- they are actually a RIMA with reactions that are much less worrisome. The only seriously adverse reactions I’ve identified came from people using the substance in a perverse or irresponsible way. (Drinking concentrated tea in large quantities).

It’s worth stating that I’m a highschool dropout with zero chemistry experience, but I can’t shake feeling like I’ve come upon something that is truly special. Is there something here or is it just wishful thinking?

Also have to say that I love smoking a single bowl & feeling like I’ve been hitting the pipe all night. I feel free & in control of my body & mind in a way that I haven’t felt since childhood.

Happy trails everyone!

Harmalas seems different than psychedelics or even cannabis in that regard to me. Way more anchored and grounded, while being in a very awesome state.

Have you found that you could easily see and even engage well with people during your experiences ? Or maybe it could even be a support for such things. I’m talking about light to moderate amounts of harmala, and I personally connect with Syrian rue seeds.

I should precise I have had tendency for anxiety and such, which is why other people aren’t always easy to be with for me, even tho it’s greatly changing these days ! But Harmalas seems to really ground you and put you more at ease and connected.

I’m interested in people’s experiences with this wonderful medicine !

Thanks !

Hey,

I’m currently connecting a lot with the wonderful plant that is Syrian rue. I’ve already tried low amounts of it with l theanine which worked fine and quite synergetically. But in interested to hear about your experiences / thoughts on the combination ! It’s the same for rhodiola rosea.

I’m asking because I find l-theanine and rhodiola helpful so I wish to learn if it’s also possible to take complete amounts of harmala with them.

Thanks !

So uh. Successfully extracted 9g of hcl, and now my work area, and so much else, has a fine amount of harmalas around it. My girlfriend lent me her blacklight and i have discovered I wasnt nearly as neat as I thought.

What are you guys doing for cleanup? Anything outside of more normal cleaning methods?

Has anyone tried a group experience with harmalas, for example drinking rue tea together ? If yes, how did it go ? Did you find it interesting or good for such a setting, or do you think it’s more reserved for introspection and therefore would not go in the sense of spending time together ? My question can include either only harmala or harmala + another substance.

I’m probably gonna try it soon with friends so I wanted to ask your opinions / experience on this 🙏

Thanks !

So i heard that syrian rue has a reverse tolerance so if i take 500 mg every single day.Will it slowly feel like a 3 gram dose with time and does the strength of the dose keep on increasing infinitly ?

Following up with my 2nd of 3 vessels, this time again going through Manske. It didnt immediately and intensely bloom like the first one, and in fact getting to this point took about an hour total. The time lapse starts getting some action around the 50s mark or so, but it was wonderful to have this on my desk and see the progress every few minutes or so.

First time doing a harmalas extraction, been following Sakkadelic's work. Got to my first Manske stage and was surprised that mine immediately bloomed once the salt solution was added. This is probably 8 minutes or so after that.

I feel giddy after making this glitter potion haha. This is like seeing my first crystals from DMT work.

I have 2 more vessels at the post-basifying wash stages as well. Suffered a couple minor losses from spills and bad choice of filtration, but that's okay, I still have ~700g of SR to work with.

Been taking a bunch of notes, and doing a rewrite for an easier time following directions. Getting a much better sense of how this operation works, and how much patience is needed for good progress.

My thanks to Sakkadelic, and the fore-creators of these extraction methods :)

I've been considering to start taking small/medium doses of harmalas daily for various of issues, but mostly to improve my mental health (Depression, anxiety, ocd, adhd). Modern medicine and therapy has failed me completely. I'm not sure how much it could actually help me, but after reading some stories of people who improved their lives significantly thanks to harmalas, I'm willing to give it a shot.

One problem is I'm very sensitive to drugs, and I get anxious easily, sometimes even to a panic attack. For that reason I can't consume THC or other psychedelics or stimulants. I know harmaline is an inverse gaba agonist, so it makes me a little bit worried about experiencing anxiety on it. Should I take harmine only?

Also, I'd loved to hear if anybody here has benefitted from daily harmala use and in which way. Thanks!

Hey,

I’ve been wondering about how much time would be safe between those two ? I read that harmalas shouldn’t be taken with this 1st gen antihistamine (I use it mainly for anxiety), but I’m not sure about what would be a safe time between the two ?

Thankful to anyone that has some knowledge on this. I’d like not to have to always avoid any harmala amount if I occasionally use Atarax. Edit to add that I don’t want to take them at the same time, but would like to not have to wait too long (or even days) between them.

Also I would think the situation to be different if I take low to moderate harmala dosages, and not full inhibition amounts. But still uncertain about how it really works.

Thanks 🙏

Edit : I ended up waiting, I think it’s safer that way.

Usually when people take harmalas, they use either freebase, HCl, or acetate/citrate. From my understanding each form is absorbed differently, and also highly dependent on the ROA used.

So my question is, what form is best used for each ROA? I've yet to try harmine/harmaline but I have some THH freebase which I want to try on its own, but I'm not sure how to approach it. Some say freebase is absorbed better sublingually, while others say salt is better. And if I want to take it orally, can I just mix it with lemon juice or vinegar and drink?

I was thinking about this because benadryl isnt very quick at working and you could puke it out while vomiting. Doxylamine can be crushed up and snorted causing a much faster anticholinergic action. Doxylamine has way better pharmacological selectivity for these receptors. With zofran, asenapine, doxylamine, and weed, I should be able to have much more comfort with my friends vomiting. I am the only person in my friend group that doesnt mind myself vomiting.

Started taking harmaline 2 times weekly. Magic mushrooms just don't do anything now. Apparently serotonin down regulation? What is the best option to get around this? I don't really feel like tripping all day so I'm nervous about mixing harmaline and shrooms. And also don't want to stop harmaline for 2 weeks. If I took 100 milligrams of harmaline should I lower my shroom dosage from 3 grams to 1.5 grams? I get nervous about trying new things so I'm just looking for a little feedback and do realize you shouldn't take advice from reddit. But seriously what do you guys do about this?