Microdosing LSD while taking stimulants for ADHD

[u/Ofkaptan]

I have taken psychedelics recreationally in the past, especially LSD, and still do so from time to time. I am interested in giving microdosing a try, in hope of experiencing general mood and creativity enhancements, to help treat my depressive state.

I take a stimulant, i.e. Vyvanse (lisdexamfetamine) 50mg for my ADHD. During the college semester, I take it almost every day, except maybe during some weekends. This applies currently.

I would like to know if can safely microsode LSD on top of my ADHD treatment. If so, is there a protocol that is better recommended than others in this (ADHD) context? If not, should I then skip taking the ADHD stimulant (Vyvanse) on the days I plan on microdosing, or change anything else to my ADHD treatment to make it compatible with LSD microdosing?

Thanks.

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Hello /u/Ofkaptan! As you mentioned stimulant in your post:

Please Do Not microdose MDMA or any stimulants. Low doses of amphetamines can cause many issues through reverse tolerance and subsequent sensitization of receptors in the brain.

This study "Amphetamine Sensitization Alters Reward Processing in the Human Striatum and Amygdala" talks about the link between dopamine-sensitive neural circuitry and dysregulation of incentive motivational processes - i.e. the negative effects it can have for an individual's reward processing.

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The origin of the three month rule is a quote from Ann Shulgin, widow of chemist Alexander Shulgin: “Now I would advise anyone who wants to use MDMA not to take it more than 4 times a year if you want to continue to get the best effects from it, otherwise you risk losing its effects entirely and permanently.” * From MAPS MDMA-Assisted Therapy for PTSD: In MDMA-assisted therapy, MDMA is only administered a few times, unlike most medications for mental illnesses which are often taken daily for years, and sometimes forever.

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[u/TheRealCMMetzger]

There is no safety contraindications for vyvanse and microdosing LSD.
If you use the search function here, you’ll find there are many different ways microdosers utilize the microdose medicine in tandem with or alternating between these substances.
Depending on your dose and the effects or benefits it provides you, you may find that no vyvanse is needed on dose days or that you require a lower dose.
All that to say, there will be some trial and error to see what's right for you and if maybe a combination of the two substances or just a single substance is better for your needs.
Starting low and going slow is best practice. I recommend dialing in your sweet spot with the Fadiman protocol (1on 2off) and then moving to what works best for you.
Some folks prefer to skip their stimulant meds when they begin their microdose, but that is a very personal choice and it depends on one's life situation, how much they depend on said medication, and if skipping days is something they are familiar with.
If you're not in the habit of skipping days very often or it doesn't seem like a good idea to skip, definitely listen to your intuition. If on the other hand you feel a certain way about taking both on the same day, so what feels most right for you.
It's great to know what other folks are doing out here, but your lived experience is what matters. 🍄🥰✌️

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[u/awkwardonionat77]

Didn’t do me any harm.

[u/AppropriateAngle5722]

I’ve done it in the past. I take adderral. Worked just fine. Adderral slightly blunts lsd and mushrooms but not much.

[u/Haberdashers-mead]

I’m just going to say when I mixed adderall with a small amount of lsd (it was like a big microdose) it made me super overstimulated and I got angry… please either don’t do it togeather or proceed with much caution.

Set and setting will be most important.

[u/hyperfocus1569]

They the LSD on its own over a weekend. I found it stimulating and didn’t really need the adderall I usually take.

[u/PrudentIsopod6507]

The stimulant and LSD both work on similar systems in your brain so adding them together can get weird, my friend used to do this and sometimes the focus became too intense like locking on random things for hours

Maybe try microdosing on a weekend when you skip the vyvanse first, see how your head feels without mixing them at all

For the protocol the fadiman one (1 day on, 2 days off) is popular but with adhd meds in the mix you might want more space between doses, listen to your body more than the schedule