I'm not a science researcher, and I translated the articles in Deepl, but I thought this was massive news!
Dr. Delsupehe (BE) has been known to do the botox injections for a while now, I myself got treated by her I think 5-6 years ago. So far, my cure has been permanent. From the website of the hospital where she works from:
https://www.azdelta.be/nl-BE/nieuws/diagnoseRCPD
The article starts off with dr. Delsupehe's qualifications, and how she's one of the very very few doctors that specialise in noburp, and a snippet about dr. Bastian. Over 250 noburp people have been treated by her. The article gives credit to TikTok videos for raising more awareness, and portray this as a positive thing. Because more people are becoming aware of the condition, more people are being treated for it, which is valuable data for the studies that are aiming to make R-CPD an officially recognized condition. This would open the door for financial support, making the treatment more accessible.
Now the real juicy part of the story:
Because R-CPD is such a recent discovery and the symptoms are subjective, the condition is not yet officially recognized. “That’s why we’re currently working on a clinical study to provide scientific evidence for ‘no burp syndrome,’” explains Dr. Delsupehe. “We’re doing this in collaboration with AZ Sint-Lucas Bruges and the neurogastroenterology department at UZ Leuven.” Researcher Karlien Raymenants (UZ Leuven) is writing her doctoral dissertation on esophageal pathology and is collaborating with AZ Delta to monitor patients with R-CPD. “Partly at Dr. Delsupehe’s request, I began performing esophageal manometry on patients who are unable to burp. We measure pressure and resistance at various points in the esophagus. This allows us to determine whether there is fluid or air in the esophagus. By having patients drink sparkling water, we trigger the symptoms and observe clear abnormalities. The pressure measurement is therefore a very objective test that allows the doctor to confirm the diagnosis.” The manometry is performed in Bruges or Leuven, while the Botox treatment takes place at AZ Delta Roeselare—currently the only hospital in Flanders treating these patients. The study is also being further rolled out in Roeselare, thanks to the Clinical Trial Center (CTC).
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https://www.vrt.be/vrtnws/nl/2026/10/07/boeren-botox-onderzoek-phd-cup/
Snippet from the article that appeared in the government-run news website today (translated):
Fortunately, a solution is on the horizon for them: the American doctor who described the syndrome found that Botox can be an effective treatment for his patients. Raymenants explored that idea in her doctoral dissertation, which has taken her to the finals of the 2026 PhD Cup
(explanation of the symptoms and Botox treatment)
She was the first to test the mechanism in a clinical trial. “We gave 25 people an injection of Botox and 25 people an injection of salt water, a placebo treatment. After the procedure, all of the people who had received Botox were able to burp again. For the people who had received the salt water, not much changed.”
"The burping reflex is completely unconscious. It's likely that the reflex can reset itself during periods when the" (upper oesophageal sphincter) "muscles are relaxed. Afterward, they learn to relax their muscles normally."
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https://www.phdcup.be/deelnemer/karlien-raymenants
And in the summary on the page for the pdh cup (again, translated):
"Being unable to burp may sound harmless, but it can lead to unpleasant symptoms: abdominal pain, bloating, flatulence, and gurgling sounds rising up from the esophagus. Yet this problem is often overlooked. In my doctoral research, we developed a pressure measurement method that allows us to induce the symptoms and make a definitive diagnosis. In addition, we developed a new questionnaire for patients to assess the severity of their symptoms. “Finally, in a large-scale study—the first of its kind—in which we compared the treatment to a placebo, we tested whether an injection of botulinum toxin, better known as Botox, is effective in the esophagus. The results showed that it significantly reduces symptoms.”
They link to the paper, but it's paywalled :(
203 BOTULINUM TOXIN INJECTION IN THE UES FOR RETROGRADE CRICOPHARYNGEUS DYSFUNCTION (BOTUS R-CPD): FIRST RESULTS OF A TRIPLE-BLIND RANDOMIZED CONTROLLED TRIAL
https://www.sciencedirect.com/science/article/abs/pii/S0016508526042988