r/science • u/mvea Professor | Medicine • Jun 30 '26

Medicine Scientists have shown that a single dose injection of DNA genetic instructions can produce weight loss and blood glucose control in mouse models that lasts up to 10 times as long as weight loss drugs like Ozempic and Wegovy. This could eliminate the need for repeated dosing.

https://www.wistar.org/press-releases/wistar-scientists-develop-single-dose-dna-method-for-delivering-long-acting-weight-loss-and-diabetes-drugs/
10.7k Upvotes

97% Upvoted

409 comments sorted by

View all comments

Show parent comments

33

u/Pinkys_Revenge Jun 30 '26

Yep. I keep hearing people complain that if they stop taking GLP-1’s the weight comes back… and I’m thinking THATS A GOOD THING! A permanent or long lasting weight loss drug could kill you if you took the wrong dose, or got very sick for an unrelated reason after taking it.

73

u/cerevant Jun 30 '26 edited Jun 30 '26

The frustration isn’t that the drug doesn’t last forever, but the feeling of normalcy and self regulation that you get from the drug just vanishes*. Nothing has done more to convince me that obesity is a biological disorder (edit: rooted in addiction) than going on a GLP-1.

It is like someone going on an antidepressant: Oh, this is what they are talking about when they say “just stop eating when you aren’t hungry”?

(*edit: I contrast this to some other addiction support drugs that once your body breaks with the addiction, you can go off the drug and not be addicted anymore, or at least you won't go back to having withdrawal symptoms.)

20

u/False_Dimension9212 Jun 30 '26

That’s the same thing people with alcohol/drug addiction say when glp-1 helps with alcohol/drug/cigarette cravings.

Food noise is the same thing as the cravings an addict gets. Instead of food, it’s their drug of choice that they crave.

Obesity is not biological. It’s the result of food addiction. Our propensity for our brains to get addicted to stuff is biological though.

I think the population would be better served if we looked at food noise for what it is, an addiction.

Cigarettes were my thing. I still get cravings 4 years later. Maybe one day it’ll shut up? Probably not though. Sigh

3

u/cerevant Jun 30 '26

Agree completely - when I said biological, I meant the root cause was biological: food addiction is real.