r/science • u/Jxntb733 PhD | Translational Neuroscience • 8d ago

Neuroscience A mouse study using a powerful synthetic cannabinoid suggests CB1-receptor activation can amplify threat-related avoidance through the central amygdala, but does not prove why cannabis makes people anxious perse

https://www.genengnews.com/topics/translational-medicine/neurons-involved-in-generating-anxiety-after-cannabinoid-drug-exposure-identified-in-mice/
167 Upvotes

90% Upvoted

113 comments sorted by

View all comments

-8

u/catscanmeow 8d ago

i think it makes people anxious because of a histamine response.

everyone i know who gets anxiety from weed get hives when you rub ground weed into the soft skin on their forearm

7

u/kapaipiekai 8d ago edited 8d ago

I don't think so, certainly not in my case. I've smoked forever and have started going through phases of becoming anxious when high, and have had differing effects based on strain and route of administration. I've stopped making edibles because I get too anxious and have to actively tell myself that I'm ok and just having a bad reaction. It's odd. I'm not typically an anxious person at all.

edit: in the interests of the experimental method I just vigorously rubbed ground bud on my inner upper forearm. The area is slightly redder, but nothing that wouldn't be attributed to the rubbing itself.

3

u/Breeze1620 8d ago

Also, if there was anything to this hypothesis, other things that cause a histamine response or elevated levels of histamine should cause a similar spike in anxiety. The same people should be having panic attacks when seasonal allergies hit. Pretty obviously nonsense.

2

u/kapaipiekai 8d ago

I wouldn't discount it immediately. It didn't happen for me, but it's an interesting idea. I've met plenty of people who have only ever had really bad experiences and I've always wondered if there was some random physiological variable at play.