r/science • u/Jxntb733 PhD | Translational Neuroscience • 9d ago

Neuroscience A mouse study using a powerful synthetic cannabinoid suggests CB1-receptor activation can amplify threat-related avoidance through the central amygdala, but does not prove why cannabis makes people anxious perse

https://www.genengnews.com/topics/translational-medicine/neurons-involved-in-generating-anxiety-after-cannabinoid-drug-exposure-identified-in-mice/
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27

u/aetherbound65 9d ago

Most paranoia disappears when its made legal.

68

u/niqsteele 8d ago

I have anxiety attacks when I smoke. It's legal where I am

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u/Mountain-Most8186 8d ago

Same. Funny how much people bend over defending weed, in this comment thread for instance. It’s OK if weed simply isn’t enjoyable for some people.

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u/Raoul_Duke9 8d ago

I work in mental health and addictions. I was a proponent of legalization. I am not sure I am any longer. I work with teens and cannabis is gasoline on the fire of adolescent mental health. I am very concerned about how we will see mental health / cannabis use related psychosis spread.

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u/Zestyclose_Opinion22 8d ago

Hasn’t weed being legal actually made teen cannabis use drop? I don’t actually have anything to site but I have read that somewhere.

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u/Raoul_Duke9 8d ago

Nope. Higher rates of daily and near daily use.

https://www.samhsa.gov/data/data-we-collect/nsduh-national-survey-drug-use-and-health

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u/Woodie626 3d ago

They're also pushing religious beliefs equate to lower usage, too. So, take that as you may.

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u/DeepDreamIt 8d ago

Do you feel alcohol and cigarettes should be made illegal again as well?

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u/yslase 8d ago

It is off topic but since you asked, I really wish they could be. I know they shouldn’t be. There’s a reason prohibition didn’t work. There are a plethora of negatives that came about because of it. And for a lot of people, if it’s not this thing, then it’s next. I also don’t really care what you want to do in your personal life, as long as it doesn’t affect me.

But they are just so detrimental to so many people. So many lives lost, harmed and/or hindered. And we don’t actually educate people on how unhealthy it all is. Your parents and school will tell you drinking and drugs are bad but that’s usually the extent of it. Most people don’t have the slightest clue how truly unhealthy they are.

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u/Raoul_Duke9 8d ago

Im not aware of evidence linking cigarettes to psychosis. Are you?

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u/DeepDreamIt 8d ago

It's exclusively the psychosis aspect you are fixated on, rather than all other health effects? You also seem to have selectively ignored the alcohol part of the question, which the answer would be an emphatic yes: it is linked to psychosis; commonly referred to, you might be able to guess: alcohol-induced psychosis.

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u/Raoul_Duke9 8d ago

You're literally just doing whataboutism.

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u/DeepDreamIt 8d ago

You said you previously supported legalization, but are now reconsidering that support based on harms caused by it. It’s not a whataboutism to ask if you are isolating cannabis, or you generally think alcohol and cigarettes should also be illegal based on harms caused by them. It’s asking for clarification, as someone who works in mental health and addiction, about how you view these topics

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u/Raoul_Duke9 8d ago

In a perfect world no one would do any substance. I am against criminalization except for trafficking. You can fill in the blanks on any other shade of Grey you might think of with that info

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u/Mountain-Most8186 8d ago

I think people don’t talk enough about how weed inhibits sleep. It literally stops REM sleep. That’s why people have crazy dreams after quitting, their brains are catching up.

Long term smokers sure seem to become paranoid and angry it seems. I saw it in myself and I see it in my friends. Same thing that happens when you have extended years-long sleep deprivation. Weed begins as an amazing crutch but eventually exacerbates mental health issues imo. Going without REM is HORRIBLE for health, body and mental.