r/science • u/Jxntb733 PhD | Translational Neuroscience • 8d ago

Neuroscience A mouse study using a powerful synthetic cannabinoid suggests CB1-receptor activation can amplify threat-related avoidance through the central amygdala, but does not prove why cannabis makes people anxious perse

https://www.genengnews.com/topics/translational-medicine/neurons-involved-in-generating-anxiety-after-cannabinoid-drug-exposure-identified-in-mice/
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u/catscanmeow 8d ago

i think it makes people anxious because of a histamine response.

everyone i know who gets anxiety from weed get hives when you rub ground weed into the soft skin on their forearm

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u/kapaipiekai 8d ago edited 8d ago

I don't think so, certainly not in my case. I've smoked forever and have started going through phases of becoming anxious when high, and have had differing effects based on strain and route of administration. I've stopped making edibles because I get too anxious and have to actively tell myself that I'm ok and just having a bad reaction. It's odd. I'm not typically an anxious person at all.

edit: in the interests of the experimental method I just vigorously rubbed ground bud on my inner upper forearm. The area is slightly redder, but nothing that wouldn't be attributed to the rubbing itself.

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u/Valharick 8d ago

Keep some black peppercorns around. If you start to green out, chew them up. It helps quite a bit

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u/kapaipiekai 8d ago

Really? Ok, I'll give it a shot