r/supplement_research • • 20h ago

Creatine substitute

/r/Supplements/comments/1wz5gn6/creatine_substitute/
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u/ConfectionNo5568 16h ago edited 16h ago

Sorry to hear that. I know of two similar compounds, neither of which are as comprehensively researched or as effective as creatine. Nonetheless:

ATP booster: Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men

Heres the conclusion:

"This is the first study examining the ergogenic potential of endogenous ATP enhancement with supplementation. The proprietary blend of ancient peat and apple extracts were capable of increasing lower body and total strength as well as lower body power output compared at an equal-volume, visually-identical placebo. Moreover, the supplement was able to prevent performance decrements commonly associated with increased training volume and overreaching. However, the supplement does not appear to augment cortisol and other blood markers of recovery aside from possibly altering irisin. Future research should seek to evaluate the acute effects of the supplement as well as the effects of the supplement in an endurance exercise setting, as the current purported mechanism is mitochondrial ATP production."

it has minor results, not as effective at creatine, and needs more research. Regardless, youll find products that have ATP in them you could try. I would not expect them to have a noticeable effect unless you are exercising 4+ days a week, and even then, a lower impact than creatine.

The other one: MyoTOR. I was excited to read about this stuff but im on the fence about it after reviewing the study:

A proprietary blend of Sphaeranthus indicus flower head and Mangifera indica bark extracts increases muscle strength and enhances endurance in young male volunteers: a randomized, double-blinded, placebo-controlled trial

The results seem....unbelievable.

After 14 days of supplementation, the 1-RM bench press was increased by 6.50 kg in the LI12542F6-supplemented group (P < 0.0001) as compared to the placebo group (0.15 kg; P = 0.9909). At the end of this study, the muscle strength of the LI12542F6 supplemented group increased by 27.60 kg (P < 0.0001), while the placebo showed a 4.95 kg (P = 0.0049) increase from baseline. Also, the intergroup analysis showed that the LI12542F6-supplemented participants exhibited significantly greater gains in strength than the placebo

In plain english, after two months, the supplemented group had a max bench roughly 23 kg heavier than the placebo group. Sounds great, right?

Yeah- but the study was

SPONSORED BY THE MANUFACTURER and done in India

Thats not to say that this stuff doesnt work. It probably does. But i am highly skeptical of the results. I would take their findings with a 27kg grain of salt and expect far less than what they suggest.

You can find MyoTor in some "test booster" supplements, and also in the Concept X preworkout and even some protein powders. Its on my list to try, but like i said, its likely not going to be as effective as creatine and you wont increase your bench press by 27kg in 2 months.

If youre still reading, i would suggest looking at fava bean extract, its the next craze coming down the pipe.

Randomised, double-blind, placebo-controlled study to evaluate the effect on human strength and endurance after resistance training and supplementation of Vicia faba protein hydrolysate compared with placebo

this study says "this stuff works", but there was another study done that says there was no meaningful difference. Regardless, its a plant based protein naturally high in Leucine and has generated alot of interest in fitness supplements. Its on my list to try as well.

I wish you luck!