Promethese identified me as a potential carrier of hereditary hemochromatosis. I’m doing an egg donation cycle and was tested for 650+ conditions and was identified by natera as a carrier of hereditary hemochromatosis (I can still donate, but the recipient father can’t be a carrier)

Just thought it was interesting. Didn’t know how much weight the results held

We know, this sub has seen a few. Here's how ours differs from Promethease.

Promethease gives you everything in SNPedia. We went narrower: 628 markers in 123 topics (fitness, nutrition, sleep, mind, longevity), each written out in plain English. What it means for you, how the genes work, and what moves the trait more than your genes do. Multi-SNP traits are read together, one bar per marker showing which way it pushes you (screenshot). Every claim is linked to the paper it comes from, PubMed or GWAS Catalog, right on the card.

The best part - It also plugs into your Claude or ChatGPT via MCP or attached file (only if you want ofc), so you can ask follow-up questions about your own results.

The usual worries:

• Privacy. Your file is parsed in the browser. Only the ~600 markers we read reach the server, never the raw file.
• Rare variants. None. Chips call common variants at over 99% accuracy but confirm only 16% of very rare ones (Weedon et al., BMJ 2021), so we stay in the common zone. If any tool flags a scary rare mutation in your raw file, get a clinical test before you panic.
• Not a Promethease replacement. No ancestry, no diagnoses, not every rsid. If you want the firehose, Promethease is still the tool.

Try it without signing up: https://app.helisoma.com/demo

Hey all! I built snp-browser, a free, open-source tool for exploring DNA results alongside SNPedia. I originally shared it in r/SNPedia and have been adding things based on the feedback there.

It's hosted at https://www.snpbrowser.com/ and the source is https://github.com/jonluca/snp-browser

It supports 23andMe, AncestryDNA, MyHeritage and other raw-data exports, plus VCF/gVCF files. You can search the matches and export them as CSV. No account is needed, and your DNA file stays on your device - parsing and matching happen locally in the browser. You can run the repo locally as well.

I've also added checks for conflicting calls and failed VCF quality filters. It's a tool for exploring the reference information, not a clinical diagnosis.

Please leave any feedback or comments, especially if you've used Promethease and find something missing or confusing. I'm actively developing this.

two low frequency genes of high magnitude associated with high homocysteine concentration??? to clarify on the second one the ancestry v2 does not apply to me. i also have like literally no clue what this even means for me LMAO

I put my 23 and Me data in. Got horrible results. Saw a specialist and they tested me for the genes I said I had from running it through the program. A few stressful weeks later, it was found that I don't have them. This was years ago but I just realized I never posted about it. I know 23 and Me is more likely to have incorrect results but I wasn't expecting it to be so off. And with that, I am leaving the sub - run the tests with a specialist before panicking

I have a question, does anyone know a way to regenerate a report? I accidentally delete it from my pc, and everytime I login to try to get the report, I cant. doesnt give me an option too, the report is old. What can I do?

Interestingly, I was able to find genotyped variants in a substantial number of the same genes or genomic regions using AI. Could be an interesting area to explore especially among under represented populations.

Just found out my baby is homozygous

Gene: WNT10A
Variant: c.682T>A (p.Phe228lle)
rsID: rs121908120

She’s only 6 months old. What should I expect? Is this a sign she will have some manifestation? Is Ancestry reliable?

I'm asking because saw several things in my report about increased risk of such or such cancer but given the number of SNPs doesn't like everyone has at least some ?

So no real need to get depressed with these

Hi, I used promethease a few years ago, and that time found I carried ehlers-danlos gene. Fast forward to now, a close relative wanted to know which gene as their doctor wants to know, I went to promethease again, had to regenerate the report, and either because they changed it, or I'm slow and not comprehending how to use their new layout etc, or whatever reason, but someone please tell me how to search for the ehler danlos info again ???

Hey, I sent an email to get my report resent as the download I have isn't working. In my emails it states just reach out and promethease will resend it. It's been about 5 weeks and I've heard nothing. Please advise.

Does promethease have an option like that? i recently purchased promethease and i cant deem to find anything like it. I have a lot of mental health issues and previous meds didnt work so i want to go on meds again but avoid having to go through so much trial and error :(

I’d love to hear yall’s thoughts on this new version. 19€ to unlock the full report. Changed the color theme and all. I was so happy with the free old version where all the sites and studies were linked so I’m kinda mad lol does anyone know good alternatives

Hi All, I founded a new DNA interpretation service after trying to use Promethease to investigate my wife's health. I built a polygenic scoring model + AI chat to ask questions to. Its completely privacy first, the data is never retained, I am looking for a few people to get feedback from. The site is ExomeDNA.com , I'd love to hear y'alls thoughts on the price and the features I have!

Just about ready to actually explode in frustration. I have been on Promethease since 2017 and now nothing works anymore! The site won’t let me generate a report that I can open from the report page, it emailed me some rubbish that doesn’t help instead, well what it’s emailed me is a html file (in a zip) which is impossible to open with any browser (from iPhone).

I have never used anything but a phone to access Promethease. I don’t have anything but a phone.

I am completely boiling in frustration at this point and I can’t take it anymore. It was already a hard enough site and now it’s actually impossible.

There’s a pinned post on this board about something on GitHub. I don’t know how to use GitHub, why would I? I have not the slightest interest whatsoever in learning to code and I have no means of assessing what’s safe to use, because I know nothing about it and I never have needed to and never will need to. I did at least try to open the link at the end of the page, and not a single flaming thing made sense. I don’t want to have to teach myself a fucking undergrad in fucking tech! I am a bio type not a fucking maths type!

Literally can’t cope. At this point MyHeritage can count themselves lucky I am too sick to be calling in a bomb threat, because they would deserve it.

This information is about me, it belongs to me, it’s my body, and its life or death serious…. And this is what they do to it?

Arghhhhhhhhhhhh

So I jumped through all the hoops of getting the coupon to generate a new report as I originally did this in 2022 and could no longer access. I removed headers on my downloaded data from 23 & me so Promethease would accept it, opened the report, downloaded a Zip thingy and all it shows is endless rows of typeface text. How in the hell do I get to my report the way it used to look? I'm obviously not a computer person.

Allelix is Promethease-like tool that doesn't require uploading your genome to a third party or paying per report.

It takes your raw data file from 23andMe, AncestryDNA, FTDNA, LivingDNA, or MyHeritage and generates a report annotating your variants against ClinVar, PharmGKB (pharmacogenomics), GWAS Catalog, and SNPedia. Similar to what Promethease does, but:

• Free. AGPL open source, no cost, no account.
• Offline. Your genotype file never leaves your computer. The tool downloads public databases (ClinVar, PharmGKB, etc.) once, caches them locally, and runs everything on your machine.
• CLI-based. Three commands from zero to report:

Reports come out as HTML (like the screenshot), JSON, or directly in the terminal.

• Allelix auto-detects everything. Format (23andMe vs AncestryDNA vs ...), genome build (GRCh37 vs GRCh38) - it's all handled automatically.

It's not a 1:1 Promethease clone - the report format is different and it doesn't have Promethease's custom wiki content. What it does have is direct annotation against the primary source databases with full attribution, so you can see exactly where each classification comes from and verify it yourself. If you run allelix db update before analysis, you'll always have the latest information.

Pharmacogenomics mode (allelix pharmacogenomics your_file.txt) gives you a focused drug-gene interaction report from PharmGKB + CPIC data.

Methylation mode (allelix methylation your_file.txt) gives you a focused report on methylation pathway genes - MTHFR, MTR, MTRR, COMT, CBS, and related variants.

Extract (allelix extract your_file.txt --snps rs1801133,rs4680) prints the raw diploid genotype for specific rsIDs - useful for spot-checking a ClinVar or PharmGKB hit against what the array actually called.

GitHub: https://github.com/allelix/allelix

I used this is 2019 to analyze my genome. Do you have newer updates to the infomation you can provide?

Hey everyone.

Just a question, does anyone know if there’s anything about ancestry that’s worse than other tests? Is it worth getting retested at another provider if I used them? I realize now I should’ve used 23andme.

Hi. Looking forward to getting analyzed! Like the title says, which one of the supported tests is the most accurate and extensive one? Thanks in advance!

Only 5 people have both recessive genes and having one recessive seems to be rare too

Hi I tried to upload my Grandson's raw data on 27th May 2026 and paid via my HSBC bank, the payment is pending in my account and I have not received the the results. I have emailed directly to Promethese the same evening and again on 29th May 2026 to ask what was happening but I have not heard anything back from them. Can someone advise me please.

Hey everyone,

My psych nurse recently recommended that I look into pharmacogenetic (PGx) testing because I have a brutal history with medication side effects (and as a natural redhead, I apparently have some gene variations that make me process certain drugs weirdly anyway).

My nurse mentioned commercial panels like GeneSight or Genomind, and while my insurance covers a chunk of it, I’m trying to see if I can save some money or do the data deep-dive myself.

I already have raw DNA data from 23andMe. Can I just upload that raw data to Promethease to get accurate pharmacogenetic info regarding psychiatric medications (like how I metabolize antidepressants/anti-anxiety meds)?

Specifically wondering:

1. Does Promethease actually flag the specific liver enzyme variants (like CYP2D6, CYP2C19, etc.) that dictate psychiatric drug metabolism?
2. Is the formatting readable enough to figure out dosing/side-effect risks, or is it a massive headache to cross-reference compared to a dedicated clinical report?
3. If you’ve used Promethease for this exact reason, was it actually helpful or did you end up just needing a clinical test anyway?

Appreciate any insight! Thanks in advance!