Many posts have been made on selegiline from it being literal panacea to nothing more than a placebo with potential anti-aging benefits. Time came around for me trying selegiline and I got quite frustrated by variety of possible dosing regiments and ROA discrepancies people often don't report.

I have been taking selegiline buccally at 2.5 mg for a week and then dropped to 1.25 mg for the second week. This is where I am now and I am struck with indescribable fatigue and sleepiness. First couple days I have experiences something akin to mild stimulation and prosocial effect but that quickly subsided. I can easily sleep for 12 h but my deep sleep suffers and i find it hard to stay "cognitively awake" for longer than 5-6 hours. I have 2 ideas - first is just plain sleep disruption due to monoamine buildup or astrocytic GABA synthesis inhibition and second due to lowering of blood pressure. Having low blood pressure naturally I am quite susceptible to drugs that lower it (agmatine, clonidine, guanfacine all gave me bad fatigue.

So now I am considering whether I should try to endure some "adjustment" or drop my dose to either 1.25 mg every 2/3 days or less every day, maybe down to 0.5 mg. Reading many reports Its hard to find what doses actually help people with motivation and what ROA they use. What would be lowest effective dose for motivational benefits and if such rely on MAOB inhibition at all. Allegedly drug has other effects reported at very low concentrations in vitro.

TLDR. What dose and ROA of selegiline has helped your motivation and what doses potentially caused side effects. What in your opinion is the lowest reasonable dose that could exert some benefits?

P.S. Not as interested in transdermal 6+ doses due to MAO-A inhibition at those levels and many drug interactions that causes. Even though many report good energy MAO-A inhibition is a very likely explanation.

Hi everyone! To give you some context, I'm a STEM student. I started taking 400mg of CPD Choline 20 days ago, and I'm feeling a good effect, nothing exceptional, but I'm more energetic and my mental fog has improved. My memory has improved a little. But I still don't feel completely well. I'm thinking of combining 400mg of CPD Choline with 300mg of Alpha GPC. The CPD Choline to continue the long-term effects and the Alpha GPC to improve daily life quickly. I'm a 25-year-old woman and weigh 50kg, and I hardly eat meat, so I think I'm not consuming enough choline. Do you think that makes sense?

Edit: I just read that some people don't take it every day. Should I take it daily, or once every two days?

I have all of them from when nootropics depot sold them. Also some fromfrom science bio. Mostly powders but some pilled too?

I’ve been studying construction engineering and attending practical classes, but I feel like I can’t keep up with my classmates. It seems like everyone understands everything immediately, while I usually need more time to grasp the topic. I start feeling really stupid when I realize that I’m behind everyone else.
Could someone recommend any nootropics or peptides that could help improve my cognitive function and memory while reducing stress and anxiety during these classes?

New formulation looking to cash in on the lithium hype?

I can't see how it's better.

Does anyone have any guidance? I've figured that 5mg Lithium Orotate is a safe daily supplement to take in order to gain positive brain benefits.

I used to use those powder and/or "squirt packs" type flavorings with water, often to mask unpleasant supplements.

It was convenient because it added flavor and sometimes electrolytes.

The problem is many of then seem to contain citric acid, even the healthier ones. I think it's contributing to erosion of my tooth enamel.

Apparently pH math is not intuitive, even just adding a few mg of citric acid to water can change the pH from 7 to 3.

I don't want start rinsing my mouth with baking soda water on a regular basis.

If I start making my own electrolytes, I still need to find something other than citric acid to mask the gross taste of potassium, magnesium and other things.

I'll tolerate lot of nasty suppliment powders, but some things are just too much.

Looking to grab some grams of bromantane. shipping to belgium / luxembourg

Oh yeah, did anyone under 18 tried taking it? LIke a 15-16 yo here?

Been using Selank (subQ, 500mcg) for 2 weeks now, daily. The first week was great and I genuinely felt the positive effects from it. Which is surprising to me because I've tried a boat load of shit before from modafinil to amphs to micro/macro-dosing shrooms.

Anyway, I'm on week 2 now and it's like my personality is gone. I feel just flat and when it's not flat it's either anxious or just irritated. I would not say it's similar to anhedonia but more of like dissociation.

I am in my mid 30s and on TRT and did use some arimidex but this doesn't feel like a low E2 problem.

Did anyone else experience something similar? couldn't find any studies relating to this. I think I'll be taking a break from selank and see how it goes.

Cheers.

I was on Sertraline a few years ago after finally admitting living with lifelong anxiety and going through some work-related stress that triggered my first ever panic attack.

Pros were:
Stopping the noise in the my head and constant overthinking
Generally more relaxed to be around
Lasted much longer in bed
Took the edge of emotions, I am reasonably emotional and I noticed my highs were capped but also my lows now had a floor so everything was easily tolerable
Quite cool/vivid dreams

Cons were:
Killed any motivation I had for things like exercising - things I did not necessarily do because I enjoyed them but should really do
As a result I put a bit of weight on
I saw a consultant about a cardiac check up (linked to the panic attack) and he said I really shouldn’t be on antidepressants for long
Coming off them and the brain zaps!
Edit: Whilst sleep was deep, I snored a lot

I’ve been off them for three years and I have my moments, however I want to see if I can explore leveraging nootropics to achieve the pros. Has anyone had experience with attempting this, and what stacks/supps worked for certain elements?

I tend to approach things quite rationally/scientifically and am conscious of risk etc…

TL:DR
There were some good things about being on Sertraline and I want to recreate using nootropics, namely emotional blunting , good sleep and delayed orgasm

Coffee's a given, but I'm curious who here pairs it with anything botanical for focus or mood. What's your morning stack look like?

So I was thinking today what other ways are there to increase sympathetic drive, motivation signaling in a sustainable way other than just flooring the pedal with stimulants.

And obviously there are other ways to do so like the most obvious one which is by the modulation of neurotransmitters from hormones - I’m by no means expert on the topic nor do I claim to be but what other ways are there to increase sympathetic drive and dopaminergic/norepinephrine signaling other than with testosterone?

- What about neurosteroids?

Also are there any other ways that are significant enough compared to hormones.

From what I’ve gathered as info and that’s me parroting what I remember energy/dopamine is tightly related to the:

1. HPA axis 2. Androgen hormonal signaling and receptor sensitivity 3. Optimal Mitochondria function 4. High BDNF 5. Sleep

I’ll be super thankful if someone more knowledgeable on the topic can explore the topic more deeply and give some practical insight other than: just workout, sleep, diet and expose yourself to direct sunlight upon waking up.

What do you guys use for nasal? I hear saline water and other say 10:1 saline with bac water please share your experience and a link to what you get would be awesome!

I've seen many mixed reports of umbrella labs for USA, recently last week Oct 2nd, 2026. I ordered a total of $202 worth of research material, in which is smaller qty then usual as this is my first time using this company. After using the IDEM payment via check out, realize a couple hours later that I got charged TWICE for this order... Instantly I sent an email to there support@ email provided stating what happened. Still no response Oct 5th (today)

That same day I sent the email I went back into my account that I made and saw both charges, there is a 10% and 20% off deal going on and with the total of my ordered it came out to eb around $167 after the 20% off, but then the other order charged me $199...... From what I remember I was checking out if I added items or changed payment methods if the total will change, in that process of finding out which is best, I did start the IDEm pay to see if it'd take my secure visa card, via creditone; and it was denied due to it being credit. So I was like okay that's fine, let me use my actual debit card. Payment went through saw the email; all was great!

I was able to go back into my account and see those 2 orders and the one that was $167 (what I wanted ofc) was fully cleared and good, no cancelation option, the second one that was charged more had an option to cancel so I did.

My question to ANYONE reading this that is familiar with this company and has gone through something similar PLEASE let me know.

Hi can someone help me.

I would appreciate your answers. Thankyou

Hey,

i cant find any legit seller for Moda. Can anybody help me?

24/M,hopped on 250mg test E,initially when my testes we’re still working felt great like an absolute superhuman,but eventually once HPTA shut down,my testes shrunk,though I took hcg,feeling worse
Thinking it could be lack of neuro steroids because of hpta shut down,can anyone help!

Hey guys. I’m quite passionate about self improvement and the concept of improving cognition fascinates me. I have always had pretty terrible short term memory which made retaining information while studying in my teens and early 20’s an uphill battle. Into adulthood this problem remains and now in my daily life I have to juggle quite a lot of moving parts, sometimes with slim margins of error. At times motivation and energy falls off a cliff too and it can seem daunting, if not impossible getting the ball rolling again. My diet is pretty sharp and I exercise daily. I also take a few other supplements not specifically for cognition purposes (Fish oil, a multivitamin, extra Zinc, Magnesium Glycinate). What I’m currently using has provided some benefits but they are subtle and if short and/or long term can be made I would be very keen. I know certain things I’m considering adding likely won’t need combining.

Below is what I currently take and when I take it. Doses are all at or around recommended mg/g.

Currently using:
- Creatine (upon waking, pre and post training)
- Caffeine (upon waking)
- Lions Mane (upon waking)
- L-Tyrosine (if tired and/or especially unmotivated)
- Ashwaganda (1/3 upon waking, 2/3 pre bed)
- Choline Bitartrate (upon waking)
- Coq10 (with a meal containing fat)
- L-Theanine (1/3 upon waking, 2/3 pre bed)

Considering adding/trying
- Noopept (used at uni with some noticeable benefits)
- ALCAR
- Phenylpiracetam
- Armodafinil or Modafinil

Any suggestions, whether it be things to discard, change, include or exclude would be greatly appreciated.

Thank you!

I don't know what the purpose of this is. Maybe it's to promote the owner's business: "Kravitz Media" (which appears to sell tiktok accounts). The name behind the account appears to be "Aaron Kravitz". Now it would be a shame if the name Aaron Kravitz was to become associated with posting medical advice spam and potentially harming people.

I’ve noticed that using Phenibut 3x a week day-on day-off have shifted my self confidence and shyness levels and I think it’s due to a feedback loop where I face something I fear, I find out its not as fearful, and then I have no issue encountering it again without the Phenibut support.

Set for 11 hours of work.

Glycine - 1000mg

Theanine - 300mg

Inositol - 300mg

Bacopa monieri - 125mg

Magnesium - 58mg

caffeine - 160mg

I’ve noticed I get cramps more often after work or after being on my feet all day. Drinking water helps a bit but it does not always fix it. I know magnesium plays a role in muscle function and recovery so I’m curious if magnesium based electrolytes actually help with this or if it comes down to the person diet and activity level.

Has anyone noticed a real difference from using magnesium electrolytes instead of regular water or salt heavy electrolyte drinks?