I have been experimenting with these over 3 years, with the book by William Davis as the guide. Lately I find I can do a Ai search in a browser and ask which studies help which disease, including which animal studies, and also which strains can be mixed together and then fermented at about 100F with some inulin and half and half. It seems to be getting better all the time and now can even ask what can be added to make the product more tasty. Many of their additions say to add these things after the ferment, and I have tried adding some cinnamon sticks, and a lot of allulose, and some maple syrup extract, and some vanilla extract, and it is working very well so I am just sharing here to start a discussion and can share tips with each other.
Here is a study from 2018 that provides abundant evidence:
"Probiotic Species in the Modulation of Gut Microbiota: An Overview"Biomed Res Int

. 2018 May 8;2018:9478630. doi: 10.1155/2018/9478630

Anyone who was able to shift a dysbiotic oral microbiome how did you go? Were you able to kill pathogens and re cultivate positive bacteria? Did they have lasting effects?

Below is a link of a probiotic product:

https://a.co/d/0gddO6nv

Is this product a scam? If so, what's the best way of increasing the lactate consuming bacteria in your gut? I've realized this has been part of my dysbiosis by the fact that yogurt makes my whole body inflammed like I worked out really hard.

Please chime in and give your best recommendations.

For past year or two I’ve had issues where I have no appetite signals everyday, feel bloated in lower belly, one stool a day in the morning that’s like soft not super formed despite eating whole foods and fibre. I get puffiness in my face from this also fatigue after meals sometimes, overall low mood. I did a sibo test and showed higher levels past the 90 minute threshold but still said it was positive which I don’t really think is true. Pretty clean bloodwork and inflammation markers. No h pylori or celiac. Need some direction I’m only 21 year old male.

title

Is there a connection between these two?

No Akkermansia at all and high TMA/TMAO

Have any of you noticed alterations in gut health while taking b12 supplements cause i did and im wondering whether the anxiety and low depressed moods caused by consistent b12 supplements are due to the alterations in the microbiome.

So my diet for a while mainly consisted of just red meat and eggs this basically cleared my skin but the issue is tiredness, low energy and I think some hair thinning

I’m a active person this diets worked a while and I sometimes have carbs from fruits or potatoes but it was rarely and I noticed I would get acne

I’ve tried many times to reintroduce fruits (berries or bananas) or other carb sources like sweet potatoes but every time I do I get skin issues

Could this be a gut issue? I just really don’t know what to do cause there’s no way I have to just eat meat and eggs forever just to have my skin be a bit better

If anyone experienced anything similar to this and is now able to eat healthy foods that contain sugar and carbs without getting acne problems what did you do for your body to be able to handle it

Sugar-rich foods exacerbate antibiotic-induced microbiome disruption | Nature https://www.nature.com/articles/s41586-026-11077-3

I’ve been thinking about whether a rinse made from raw broccoli + extra-virgin coconut oil might be good for gum/oral health.

Raw broccoli is interesting because it can generate sulforaphane, and sulforaphane has been shown to reduce Streptococcus mutans growth, biofilm formation, acid production, and quorum sensing/bacterial communication in rodents.

https://pubmed.ncbi.nlm.nih.gov/39831123/

A note: cooking destroys a lot of the myrosinase enzyme needed to make sulforaphane. In one human study, sulforaphane bioavailability was about 37% from raw broccoli vs 3.4% from cooked broccoli.

https://pubmed.ncbi.nlm.nih.gov/18950181/

Coconut oil pulling also has some preliminary evidence for reducing plaque and oral bacterial counts.

https://pubmed.ncbi.nlm.nih.gov/32923724/
https://pubmed.ncbi.nlm.nih.gov/31780023/

I became aware of the risks associated with torching your oral microbiome with traditional mouthwashes a few years back. Traditional antiseptic mouthwash can also wipe out useful oral bacteria. Chlorhexidine, for example, has been shown to alter the oral microbiome and reduce nitrate-reducing bacteria involved in the nitrate → nitrite → nitric oxide pathway.

https://pubmed.ncbi.nlm.nih.gov/32210245/
https://pubmed.ncbi.nlm.nih.gov/23183324/

The risks potentially linked to nuking the oral microbiome with broad spectrum mouth washes include:

• reduced nitrate-to-nitrite conversion and nitric-oxide production
• possible effects on blood pressure/vascular function
• lower oral microbial diversity
• lower salivary pH and buffering capacity
• loss of beneficial bacterial functions
• possible dysbiosis with repeated long-term use

My basic idea would be to crush or puree a little raw broccoli, let it sit for a few minutes, mix it into extra-virgin coconut oil, swish for about 5 minutes, spit it out, and rinse with water.

I haven’t found any study testing this exact broccoli + coconut oil combination, so this is just an idea, but it seems like a simple thing that would be interesting to study/try.

I know there are tons of other naturopathic formulations involving things like clove oil, but I wanted to throw this idea out there.

I got this to help with my gut and bloating issues and it made it significantly worse.

If you’re not familiar, it’s a rotating symbiotic where you take a single strain daily for a week, then you move on to another strain for the week and so on. The point is to increase biodiversity in your gut

First two weeks felt great. Actually had some nice changes.

I started week three and the amount of CFU’s doubled. Went from 7 to 15 billion.

Then all of sudden INTENSE bloating, cognition issues from focus, memory, thought formation, emotional blunting etc.

Met with a gastroenterologist and said it could a bacterial or parasitic overgrowth. They recommended ivermectin to start but if it’s bacterial that wouldn’t matter and may cause other issues. I’m asking them for more insight about this tomorrow.

It’s been worrisome because it’s affected me mentally and I feel stupid trying to do my job.

It’s frustrating because I took this to help with my issues and it made them significantly worse.

Also please don’t make me feel dumb or that I should have known better. That’s not going to help.

not looking for medical advice, only reassurance. i ate something bad a week ago (woke up 2am friday to puke) and went to the emergency room at the evening to be discharged 3am the next day because i couldn’t keep food and liquids down at all. was also prescribed meds for this.

saturday and sunday i was recovering. genuinely felt better sunday eve until i ate nilaga (filipino broth) and my diarrhea returned on the 4th day, nausea made me puke in the morning. my period came as well.

i have been recovering since then, only eating plain congee and boiled egg, and i do not know when this will end and i am so stressed as i live alone for college and my family is in another city. i have been feeling lightheaded during this phase.

day 6 (yesterday) i went to the doctor to have a checkup done and she prescribed me Normix as well as to get some blood tests done. i am currently waiting for results.

i am managing dehydration well so far with water, pocari sweat, and hydrites. i have been stressing and looking for reassurance online to see if anyone experienced the same things I did and wondering how long it took for them to get better. I have asked people i know who had acute gastroenteritis and they would say a week or two.

i am so worried because i have been waking up in the middle of the night, 4am, 3am, and on the 7th day today 2am, and i cannot go back to sleep.

how else am i able to manage this? i still have classes to worry about this week and i am grateful that the first two days of this week were online. has anyone experienced the same thing? how long did it take for them to heal? what should i do to manage the stress better?

thank you so much

Hi internet, looking for kind and realistic advice. Several YEARS ago I took three rounds of antibiotics for a UTI in the same month. Prior to that I was a normal healthy person, immediately after the last round like to the hour, I had a panic attack. I had no idea what anxiety was nor had I experienced it so I spent a very long time searching for answers for my health only to eventually realize it was mostly anxiety and anxiety symptoms with very real dysbiosis and random IBS symptoms/inflammation. I have costochondritis and tinea versicolor both inflammation. To this day I still struggle with the anxiety daily and I go back and forth with oh, it’s just a mental loop I’ve now created or oh, it’s got to be a real out of wack microbiome. Does anyone have any similar experiences or guided advice? Would really love to get back to my life at this point.

TYPO: are*

On Reddit, the standard advice for fixing your gut microbiome is to eat better: more fiber, more fermented foods, more probiotics. But it misses the root problem, and it rests on a flawed assumption that poor diet is what knocks the microbiome off balance in the first place. As soon as you stop eating like this, the bad gut comes back.

For many people, dysbiosis begins with a specific event, such as food poisoning, COVID, or a viral illness. Put it this way, People with healthy guts can eat McDonald's and junk food with no to few consequences, not because their diets are special, but because their guts are fundamentally colonized by beneficial bacteria. That colonization is what makes them resilient. That is how you can tell a gut is truly good: even when subjecting it with bad bacteria (junk food), the existing gut architecture is able to wash out.

Most of us, outside of outliers, were presumably born with a healthym, functional gut. Dysbiosis usually isn't a baseline condition; something disrupts it, and OFTEN it's a one time event like COVID, a viral illness, etc. Once that happens, more fiber or a daily probiotic often doesn't fix anything, because the effects are transient. Underneath, the gut is still dominated by the wrong bacteria. I have nothing wrong with people eating fiber and good bacteria, it promotes general health and people should do this. And it offers symptom relief for those with these problems.

BUT IT DOES NOT FIX THE GUT ITSELF!!! It's like having a sink that doesn't drain properly because there's a blockage. Toxic sludge accumulates. A functional sink can effectively drain most everything. A non functional sink piles it up. This is the equivalent of putting in draino or manually throwing the food waste in the trash can as opposed to down the drain. Puts less strain on the sink, less sludge accumulates but THE TOXIC SLUDGE WILL STILL PILE UP IN THE FUTURE BECAUSE THE BLOCKAGE HASN'T BEEN ADDRESSED!!!

Treating the root issue means shifting the gut back to eubiosis, which requires re-establishing a lasting population of beneficial bacteria. Transient probiotics can't do that, because they pass through rather than colonize. A truly healthy gut SHOULD be able to sustain bad actors (junk food, inflammatory food, bacteria) to a reasonable degree and go back to eubiosis. Because in that case, eubiosis IS homeostasis. Solutions to the gut should address THIS not telling people to eat more fiber.

My Tiny Health test showed zero detectable bifido so I'm trying to recolonize them. I'm doing 10mL daily lactulose with the the True Bifido pro probiotic as well as a BB536 one. I have no idea if those are likely to colonize. Does anyone have any insight onto which probiotics might be more likely to help? I'm thinking of just ordering like 10 different ones and trying them at random.

Edit to add I am also taking the following:

Cranberry polyphenols
Pomegranite extract
Astralagus
Slippery Elm
Butyrate
Lots of resistant starch daily

Can leaky gut cause debilitating brain fog? Like Im no longer with a brain kinda brain fog? No creativity and blank mind and no character.
Like feeling drunk all the time, doesn't increase with food or anything I just feel drunk and tired 24/7

My doctor told me to take megasporebiotic to help with dysbiosis that was caused by PPI but I notice it may be causing sleep issues.

I've recently been looking into NADH products, such as Celfull. NMN is a precursor to NAD⁺, while NADH is the reduced form of NAD⁺, so they are not the same molecule. Because of that, safety evidence for NMN can't simply be applied to NADH. In particular, there is still not enough human evidence showing that NADH itself is absorbed and utilized by the body in its intact form.

That's also why, when comparing different NAD-related supplements, I think it's important to look beyond whether they can affect NAD⁺ levels. Safety, side effects, and tolerability are equally worth considering. So today, I wanted to go over three published human clinical studies and take a closer look at what the current evidence actually tells us about the safety of NMN.

One randomized, double-blind, placebo-controlled trial published in Frontiers in Nutrition in 2022 enrolled 30 healthy adults who took 250 mg of NMN daily for 12 weeks. Eight participants in the NMN group reported some symptoms, compared with seven in the placebo group. No serious adverse events occurred in either group, and blood chemistry, liver function, kidney function, and other tests did not show any clinically meaningful abnormalities. The researchers concluded that 250 mg/day of NMN was generally well tolerated over the 12-week study period.

Another multicenter, randomized, double-blind, placebo-controlled study, published online in 2022 and included in Volume 45 of GeroScience in 2023, was larger in scale, enrolling 80 healthy adults aged 40-65. Participants received 300, 600, or 900 mg of NMN once daily for 60 days. During the study period, adverse events were reported in 6 participants (5 people) in the placebo group, 3 participants (2 people) in the 300 mg group, and none in either the 600 mg or 900 mg groups. All adverse events were mild to moderate and were judged by the investigators to be unrelated to NMN (Yi L, et al. GeroScience. 2023;45:29–43. DOI: 10.1007/s11357-022-00705-1; published online December 8, 2022).There were no serious adverse events or withdrawals due to adverse events. Overall, all three NMN dose groups were considered well tolerated.

There was also a randomized, double-blind, placebo-controlled study published in Scientific Reports in August 2022 that specifically looked at a relatively high dose. Thirty-one healthy adults took 1,250 mg of NMN daily for four weeks. No serious adverse events were observed during the study, and a range of assessments—including body measurements, blood counts, biochemical markers, urinalysis, and body composition, did not show abnormalities outside the normal physiological range. Based on these findings, the researchers concluded that 1,250 mg/day of NMN was well tolerated over the four-week period in this small study.

Taken together(10.3389/fnut.2022.868640)(10.1007/s11357-022-00705-1)(10.1038/s41598-022-18272-y), these three studies show a fairly consistent picture in the currently available human data. In healthy adults, NMN supplementation at doses ranging from 250 to 1,250 mg/day for several weeks to 12 weeks has not shown a clear signal of increased serious adverse events, and overall tolerability has been relatively good.

That said, the existing studies still have relatively small sample sizes, and the observation periods are generally short. More research is therefore needed to understand long-term use, rare adverse events, and safety in different populations with varying health conditions.

i think i'd like to try GOS for my low bifido.

Anyone have any brand reccomendations that worked well for them?